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Article

Proteasome-mediated cleavage of the Y-box-binding protein 1 is linked to DNA-damage stress response.

The EMBO journal - 19 Oct 2005

Sorokin Alexey V, Selyutina Anastasia A, Skabkin Maxim A, Guryanov Sergey G, Nazimov Igor V, Richard Christina, Th'ng John, Yau Jonathan, Sorensen Poul H B, Ovchinnikov Lev P, Evdokimova Valentina

Abstract excerpt

YB-1 is a DNA/RNA-binding nucleocytoplasmic shuttling protein whose regulatory effect on many DNA- and RNA-dependent events is determined by its localization in the cell. Distribution of YB-1 between the nucleus and the cytoplasm is known to be dependent on nuclear targeting and cytoplasmic retention signals located within the C-terminal portion of YB-1. Here, we report that YB-1 undergoes a specific proteolytic...

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Identifiers

PMID: 16193061
DOI: 10.1038/sj.emboj.7600830
PMCID: PMC1276713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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