Article
Genetic engineering in the mouse: tuning TNF/TNFR expression.
Methods in molecular medicine - 1 Jan 2004
Douni Eleni, Alexiou Maria, Kollias George
Abstract excerpt
With the exponential increase in the number of genes identified by various genome projects, it has become imperative that efficient methods be developed for deciphering gene function. Genetically engineered strains of mice are now critical research tools for basic biomedical research and for genomic approaches for the development of new therapeutic treatments for human disease. Over the past ten years it has...
Topics
- Alleles
- Animals
- Cells, Cultured
- DNA
- Embryo, Mammalian
- Gene Targeting
- Gene Transfer Techniques
- Genetic Engineering
- Genetic Vectors
- Genome
- Mice
- Mice, Knockout
- Mice, Transgenic
- Models, Genetic
- Mutation
- Phenotype
- Receptors, Tumor Necrosis Factor
- Recombination, Genetic