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Article

SMAD4 Immunohistochemistry Reflects Genetic Status in Juvenile Polyposis Syndrome

4 Aug 2010

Abstract excerpt

PURPOSE: Juvenile polyposis syndrome (JPS) can be caused by a germline defect of the SMAD4 gene. Somatic inactivation of SMAD4 occurs in pancreatic and colorectal cancers and is reflected by loss of SMAD4 immunohistochemistry. Here, SMAD4 immunohistochemistry as a marker of SMAD4 gene status and the role of SMAD4 in the adenoma-carcinoma sequence in neoplastic progression in JPS are studied. EXPERIMENTAL DESIGN:...

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PMID: 20682711
DOI: 10.1158/1078-0432.ccr-10-0168

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