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Article

NRF1 and NRF3 complementarily maintain a basal proteasome activity in cancer cells through CPEB3-mediated translational repression

2020-01-11

Abstract excerpt

Proteasomes are protease complexes essential for cellular homeostasis, and their activity is crucial for cancer cell growth. However, the mechanism of how proteasome activity is maintained in cancer cells has remained unclear. The CNC family transcription factor NRF1 induces the expression of almost all proteasome-related genes under proteasome inhibition. NRF1 and its phylogenetically closest homolog NRF3 are b...

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Literature Corpus work
101f4f0e-263b-5f7f-b695-8166769acc8c
DOI
10.1101/2020.01.10.902718
Open publication

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NRF1 and NRF3 complementarily maintain a basal proteasome activity in cancer cells through CPEB3-mediated translational repressionDOI 10.1101/2020.01.10.902718
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