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MAGI-1, A Candidate Stereociliary Scaffolding Protein, Associates with the Tip-Link Component Cadherin 23

29 Oct 2008

Abstract excerpt

Inner ear hair-cell mechanoelectrical transduction is mediated by a largely unidentified multiprotein complex associated with the stereociliary tips of hair bundles. One identified component of tip links, which are the extracellular filamentous connectors implicated in gating the mechanoelectrical transduction channels, is the transmembrane protein cadherin 23 (Cdh23), more specifically, the hair- cell-specific...

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PMID: 18971469
DOI: 10.1523/jneurosci.3833-08.2008

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

MAGI-1, A Candidate Stereociliary Scaffolding Protein, Associates with the Tip-Link Component Cadherin 23PMID 18971469Read ↗

Harmonin mutations cause mechanotransduction defects in cochlear hair cells.Semantic proximity Read ↗

Spatiotemporal pattern and isoforms of cadherin 23 in wild type and waltzer mice during inner ear hair cell development.Semantic proximity Read ↗

Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells.Semantic proximity Read ↗

Tip links in hair cells: molecular composition and role in hearing lossSemantic proximity Read ↗

Usherin, the defective protein in Usher syndrome type IIA, is likely to be a component of interstereocilia ankle links in the inner ear sensory cellsSemantic proximity Read ↗

Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells.Semantic proximity Read ↗

Cadherins and mechanotransduction by hair cells.Semantic proximity Read ↗

Compound heterozygosity of the functionally null Cdh23(v-ngt) and hypomorphic Cdh23(ahl) alleles leads to early-onset progressive hearing loss in mice.Semantic proximity Read ↗

Localization of PDZD7 to the Stereocilia Ankle-Link Associates this Scaffolding Protein with the Usher Syndrome Protein NetworkSemantic proximity Read ↗

Lack of PDZD7 long isoform disrupts ankle-link complex and causes hearing loss in mice.Semantic proximity Read ↗

Presence of interstereocilial links in waltzer mutants suggests Cdh23 is not essential for tip link formation.Semantic proximity Read ↗

Mutations in Cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1D.Semantic proximity Read ↗

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