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Article

Maternal MTHFR interacts with the offspring's BCL3 genotypes, but not with TGFA, in increasing risk to nonsyndromic cleft lip with or without cleft palate.

European journal of human genetics : EJHG - 1 Jul 2004

Gaspar Dinamar A, Matioli Sergio R, de Cássia Pavanello Rita, Araújo Belmino C, Alonso Nivaldo, Wyszynski Diego, Passos-Bueno Maria Rita

Abstract excerpt

The 677 C --> T polymorphism in the 5-10 methylenetetrahydrofolate reductase (MTHFR) gene has been associated with nonsyndromic cleft lip with or without cleft palate (CL/P) in some populations, but not others. Previous studies (ie, case-control and transmission disequilibrium tests (TDT)) in Brazilian families with CL/P have been unable to replicate this putative association. However, our group observed a lower...

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Source

Identifiers

PMID: 15054400
DOI: 10.1038/sj.ejhg.5201187

Genes

MTHFR
BCL3
TGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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