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Article

Growth/differentiation factor-5 (GDF-5) and skeletal development.

The Journal of bone and joint surgery. American volume - 1 Jan 2001

Buxton P, Edwards C, Archer C W, Francis-West P

Abstract excerpt

BACKGROUND: Growth/differentiation factor-5 (GDF-5) has been shown to be essential for normal appendicular skeletal and joint development in humans and mice. In brachypod, a Gdf-5 gene mouse mutant, the defect is first apparent during early chondrogenesis, with the cartilage blastema already reduced in size by E12.5. This defect is associated with changes in the expression of cell surface molecules. METHODS: To...

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Identifiers

PMID: 11263662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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