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Article

Distribution of proline-rich (PxxP) motifs in distinct proteomes: functional and therapeutic implications for malaria and tuberculosis

20 Jan 2004

Abstract excerpt

We have conducted a survey of proline-rich (PxxP) motifs in the proteomes of human, mouse, yeast, Mycobacterium tuberculosis and Plasmodium falciparum. Our analyses reveal a strikingly high occurrence of these motifs in each organism, suggesting a wide dependence on protein-protein interaction networks in cellular systems. All proteomes considered have an abundance of PxxP motifs which can potentially participate...

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PMID: 15047914
DOI: 10.1093/protein/gzh024

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