Article
Insights into the Immunological Properties of Intrinsically Disordered Malaria Proteins Using Proteome Scale Predictions.
PloS one - 1 Jan 2015
Guy Andrew J, Irani Vashti, MacRaild Christopher A, Anders Robin F, Norton Raymond S, Beeson James G, Richards Jack S, Ramsland Paul A
Abstract excerpt
Malaria remains a significant global health burden. The development of an effective malaria vaccine remains as a major challenge with the potential to significantly reduce morbidity and mortality. While Plasmodium spp. have been shown to contain a large number of intrinsically disordered proteins (IDPs) or disordered protein regions, the relationship of protein structure to subcellular localisation and adaptive...
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