Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity.

Current biology : CB - 1 Jan 2000

Ott M, Schnölzer M, Garnica J, Fischle W, Emiliani S, Rackwitz H R, Verdin E

Abstract excerpt

The human immunodeficiency virus 1 (HIV-1) Tat protein activates transcriptional elongation by recruiting the positive transcription elongation factor (pTEFb) complex to the TAR RNA element, which is located at the 5' extremity of all viral transcripts [1-3]. Tat also associates in vitro and in vivo with the transcriptional coactivator p300/CBP [4-6]. This association has been proposed to recruit the histone...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Gene Products, tat
Share to HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nuclear Proteins

Share to Protein Processing, Post-Translational

Share to tat Gene Products, Human Immunodeficiency Virus

Share to Trans-Activators

Source

Identifiers

PMID: 10607594
DOI: 10.1016/s0960-9822(00)80120-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity.PMID 10607594Read ↗

HIV-1 tat transcriptional activity is regulated by acetylation.Semantic proximity Read ↗

Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA.Semantic proximity Read ↗

Chromatin Remodeling and Modification during HIV-1 Tat-activated TranscriptionSemantic proximity Read ↗

Activation of Integrated Provirus Requires Histone AcetyltransferaseSemantic proximity Read ↗

Tat acetyl-acceptor lysines are important for human immunodeficiency virus type-1 replication.Semantic proximity Read ↗

The histone chaperone protein Nucleosome Assembly Protein-1 (hNAP-1) binds HIV-1 Tat and promotes viral transcriptionSemantic proximity Read ↗

HIV Tat/P-TEFb Interaction: A Potential Target for Novel Anti-HIV TherapiesSemantic proximity Read ↗

HIV-1 Tat Interactions with p300 and PCAF Transcriptional Coactivators Inhibit Histone Acetylation and Neurotrophin Signaling through CREBSemantic proximity Read ↗

Tat is a multifunctional viral protein that modulates cellular gene expression and functionsSemantic proximity Read ↗

Regulation of cellular gene expression and function by the human immunodeficiency virus type 1 tat proteinSemantic proximity Read ↗

Characterization of a Human TAR RNA-Binding Protein That Activates the HIV-1 LTRSemantic proximity Read ↗

Analysis of p300 acetyltransferase substrate specificity by MALDI TOF mass spectrometry.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.