Article
Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA.
Virology - 25 Oct 2001
Deng L, Wang D, de la Fuente C, Wang L, Li H, Lee C G, Donnelly R, Wade J D, Lambert P, Kashanchi F
Abstract excerpt
HIV-1 Tat is able to form a ternary complex with P/CAF and p300 and increase the affinity for CDK9/P-TEFb CTD kinase complex. Our previous study demonstrated that Tat binds to p300/CBP in the minimal HAT domain (aa 1253-1790) and that the interaction results in a change of conformation on p300/CBP. Here, we show that the Tat-p300 interaction increases the HAT activity of p300 on histone H4 that is associated with...
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