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The effects of graded caloric restriction: XII . Comparison of mouse to human impact on cellular senescence in the colon

25 Mar 2018

Abstract excerpt

Calorie restriction (CR) is an effective strategy to delay the onset and progression of aging phenotypes in a variety of organisms. Several molecular players are involved in the anti-aging effects of CR, but mechanisms of regulation are poorly understood. Cellular senescence-a cellular state of irreversible growth arrest-is considered a basic mechanism of aging. Senescent cells accumulate with age and promote a...

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PMID: 29575469
DOI: 10.1111/acel.12746

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