Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanical strain induces collagenase-3 (MMP-13) expression in MC3T3-E1 osteoblastic cells.

The Journal of biological chemistry - 21 May 2004

Yang Chuen-Mao, Chien Chin-Sung, Yao Chung-Chen, Hsiao Li-Der, Huang Yu-Chen, Wu Chou Bing

Abstract excerpt

Mechanical strain plays a crucial role in bone remodeling during growth and development and healing of bone besides systemic and local factors. One of the major factors involves in remodeling process is matrix metalloproteinases (MMPs) such as MMP-13 that has been shown to degrade the native interstitial collagens in several tissues. To study how mechanical strain affects extracellular matrix degradation by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Collagenases
Share to Culture Media, Serum-Free

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cycloheximide

Share to Dactinomycin

Share to Densitometry

Share to MAP Kinase Kinase 1

Share to MAP Kinase Kinase 2

Share to Matrix Metalloproteinase 13

Source

Identifiers

PMID: 15044466
DOI: 10.1074/jbc.M401343200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanical strain induces collagenase-3 (MMP-13) expression in MC3T3-E1 osteoblastic cells.PMID 15044466Read ↗

Protein kinase C-delta transactivates platelet-derived growth factor receptor-alpha in mechanical strain-induced collagenase 3 (matrix metalloproteinase-13) expression by osteoblast-like cells.Semantic proximity Read ↗

Orthodontic force regulates metalloproteinase-3 promoter in osteoblasts and transgenic mouse modelsSemantic proximity Read ↗

Mechanical Strain Regulates Osteoblast Proliferation through Integrin-Mediated ERK ActivationSemantic proximity Read ↗

IL-1 induces collagenase-3 (MMP-13) promoter activity in stably transfected chondrocytic cells: requirement for Runx-2 and activation by p38 MAPK and JNK pathways.Semantic proximity Read ↗

Effect of uniaxial stretching on rat bone mesenchymal stem cell: orientation and expressions of collagen types I and III and tenascin-C.Semantic proximity Read ↗

A three‐dimensional <i>in vitro</i> model system to study the adaptation of craniofacial skeletal muscle following mechanostimulationSemantic proximity Read ↗

Equibiaxial Tensile Strain Affects Calvarial Osteoblast BiologySemantic proximity Read ↗

Effects of mechanical strain on ANK, ENPP1 and TGF-β1 expression in rat endplate chondrocytes in vitro.Semantic proximity Read ↗

Mechanically Strained Cells of the Osteoblast Lineage Organize Their Extracellular Matrix Through Unique Sites of αVβ3-Integrin ExpressionSemantic proximity Read ↗

Effects of static or dynamic mechanical stresses on osteoblast phenotype expression in three-dimensional contractile collagen gels.Semantic proximity Read ↗

The effect of cyclic mechanical strain on the expression of adhesion‐related genes by periodontal ligament cells in two‐dimensional cultureSemantic proximity Read ↗

The effects of high magnitude cyclic tensile load on cartilage matrix metabolism in cultured chondrocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.