Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL-1 induces collagenase-3 (MMP-13) promoter activity in stably transfected chondrocytic cells: requirement for Runx-2 and activation by p38 MAPK and JNK pathways.

Nucleic acids research - 1 Nov 2001

Mengshol J A, Vincenti M P, Brinckerhoff C E

Abstract excerpt

Osteoarthritic chondrocytes secrete matrix metalloproteinase-13 (MMP-13) in response to interleukin-1 (IL-1), causing digestion of type II collagen in cartilage. Using chondrocytic cells, we previously determined that IL-1 induced a strong MMP-13 transcriptional response that requires p38 MAPK, JNK and the transcription factor NF-kappaB. Now, we have studied the tissue-specific transcriptional regulation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chondrocytes
Share to Collagenases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Core Binding Factor Alpha 1 Subunit

Share to JNK Mitogen-Activated Protein Kinases

Share to MAP Kinase Kinase Kinase 1

Share to Matrix Metalloproteinase 13

Share to p38 Mitogen-Activated Protein Kinases

Share to Transcription Factor AP-1

Source

Open in PubMed Open full text

Identifiers

PMID: 11691923
DOI: 10.1093/nar/29.21.4361
PMCID: PMC60184

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL-1 induces collagenase-3 (MMP-13) promoter activity in stably transfected chondrocytic cells: requirement for Runx-2 and activation by p38 MAPK and JNK pathways.PMID 11691923Read ↗

Recent advances in understanding the regulation of metalloproteinasesSemantic proximity Read ↗

Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis.Semantic proximity Read ↗

Cytokine-induced MMP13 Expression in Human Chondrocytes Is Dependent on Activating Transcription Factor 3 (ATF3) RegulationSemantic proximity Read ↗

Protein kinase C-delta transactivates platelet-derived growth factor receptor-alpha in mechanical strain-induced collagenase 3 (matrix metalloproteinase-13) expression by osteoblast-like cells.Semantic proximity Read ↗

Fibroblast Growth Factor Receptor Signaling Activates the Human Interstitial Collagenase Promoter via the Bipartite Ets-AP1 ElementSemantic proximity Read ↗

Matrix metalloproteinase 13 loss associated with impaired extracellular matrix remodeling disrupts chondrocyte differentiation by concerted effects on multiple regulatory factorsSemantic proximity Read ↗

Regulated Transcription of Human Matrix Metalloproteinase 13 (MMP13) and Interleukin-1β (IL1B) Genes in Chondrocytes Depends on Methylation of Specific Proximal Promoter CpG SitesSemantic proximity Read ↗

Characterization of Runx2 phosphorylation sites required for TGF-β1-mediated stimulation of matrix metalloproteinase-13 expression in osteoblastic cells.Semantic proximity Read ↗

Induction of human ADAMTS-2 gene expression by IL-1α is mediated by a multiple crosstalk of MEK/JNK and PI3K pathways in osteoblast like cellsSemantic proximity Read ↗

Mechanical strain induces collagenase-3 (MMP-13) expression in MC3T3-E1 osteoblastic cells.Semantic proximity Read ↗

Wild type and mutant p53 differentially regulate the gene expression of human collagenase-3 (hMMP-13).Semantic proximity Read ↗

Early response genes induced in chondrocytes stimulated with the inflammatory cytokine interleukin-1betaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.