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Article

Orthodontic force regulates metalloproteinase-3 promoter in osteoblasts and transgenic mouse models

4 Dec 2021

Abstract excerpt

Background/purpose Previously we demonstrated up-regulation of matrix metalloproteinase-3 ( MMP-3 ) in human osteoblasts under compression and in bony specimens of experimental orthodontic tooth movement (OTM). Here, we studied the temporal characteristics of compression stimulation in human and mouse osteoblast cell lines , and generated a transgenic mouse model for assessing the MMP-3 expression during OTM....

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PMID: 35028055
DOI: 10.1016/j.jds.2021.11.015

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