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Article

Chemokine-glycosaminoglycan binding: specificity for CCR2 ligand binding to highly sulfated oligosaccharides using FTICR mass spectrometry.

The Journal of biological chemistry - 16 Sept 2005

Yu Yonghao, Sweeney Matthew D, Saad Ola M, Crown Susan E, Hsu Andro R, Handel Tracy M, Leary Julie A

Abstract excerpt

Glycosaminoglycans (GAGs) have recently been demonstrated to be required for the in vivo activity of several chemokines. Minimally, the interaction is thought to provide a mechanism for retention at the site of secretion and the formation of chemokine gradients that provide directional cues for receptor bearing cells, particularly in the presence of shear forces. Thus, a key issue will be to determine the...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, CCR2

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Share to Spectrometry, Mass, Electrospray Ionization

Share to Spectroscopy, Fourier Transform Infrared

Source

Identifiers

PMID: 16033763
DOI: 10.1074/jbc.M505738200

Genes

CCR2
CCL11
CCL13
CCL2
CCL27
CCL7
CCL8
CCR10

Provenance

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