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Article

The MTHFR 677C > T polymorphism is associated with an increased risk of hepatocellular carcinoma in patients with alcoholic cirrhosis.

Carcinogenesis - 1 Aug 2004

Saffroy Raphaël, Pham Patrick, Chiappini Franck, Gross-Goupil Marine, Castera Laurent, Azoulay Daniel, Barrier Alain, Samuel Didier, Debuire Brigitte, Lemoine Antoinette

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, plays a major role in the provision of methyl groups for DNA methylation and in the production of dTMP for DNA synthesis. Different polymorphisms have been described for this enzyme, the most studied being the C677T,...

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Source

Identifiers

PMID: 15033905
DOI: 10.1093/carcin/bgh147

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15033905-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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The MTHFR 677C > T polymorphism is associated with an increased risk of hepatocellular carcinoma in patients with alcoholic cirrhosis.PMID 15033905Read ↗

MTHFR C677T polymorphism and risk of HCC in patients with liver cirrhosis: role of male gender and alcohol consumption.Semantic proximity Read ↗

Significant association between the MTHFR A1298C polymorphism and hepatocellular carcinoma risk: a meta-analysis.Semantic proximity Read ↗

Meta-analysis of MTHFR C677T and A1298C gene polymorphisms: association with the risk of hepatocellular carcinoma.Semantic proximity Read ↗

Genetic Polymorphism of MTHFR C677T Influences Susceptibility to HBV-Related Hepatocellular Carcinoma in a Chinese Population: a Case-Control Study.Semantic proximity Read ↗

Associations of Methylenetetrahydrofolate reductase (MTHFR) polymorphism with Hepatocellular carcinoma In Egyptian population.Semantic proximity Read ↗

Association of MTHFR and TYMS gene polymorphisms with the susceptibility to HCC in Egyptian HCV cirrhotic patients.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and the risk of primary hepatocellular carcinoma (HCC) in a Chinese population.Semantic proximity Read ↗

The association between MTHFR gene polymorphisms and hepatocellular carcinoma risk: a meta-analysis.Semantic proximity Read ↗

Significant association between MTHFR C677T polymorphism and hepatocellular carcinoma risk: a meta-analysis.Semantic proximity Read ↗

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The MTHFR C677T mutation is not a risk factor recognized for HBV-related HCC in a population with a high prevalence of this genetic marker.Semantic proximity Read ↗

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