Article
The MTHFR 677C > T polymorphism is associated with an increased risk of hepatocellular carcinoma in patients with alcoholic cirrhosis.
Carcinogenesis - 1 Aug 2004
Saffroy Raphaël, Pham Patrick, Chiappini Franck, Gross-Goupil Marine, Castera Laurent, Azoulay Daniel, Barrier Alain, Samuel Didier, Debuire Brigitte, Lemoine Antoinette
Abstract excerpt
Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, plays a major role in the provision of methyl groups for DNA methylation and in the production of dTMP for DNA synthesis. Different polymorphisms have been described for this enzyme, the most studied being the C677T, which has been shown to be associated with predisposition to colorectal cancer in patients who consume a high alcohol...
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