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Article

MTHFR C677T polymorphism and risk of HCC in patients with liver cirrhosis: role of male gender and alcohol consumption.

Alcoholism, clinical and experimental research - 1 Jan 2009

Fabris Carlo, Toniutto Pierluigi, Falleti Edmondo, Fontanini Elisabetta, Cussigh Annarosa, Bitetto Davide, Fornasiere Ezio, Fumolo Elisa, Avellini Claudio, Minisini Rosalba, Pirisi Mario

Abstract excerpt

BACKGROUND: A single nucleotide polymorphism (SNP) C677T in the methylenetetrahydrofolate reductase (MTHFR) gene has been identified. The TT or CT genotypes show a marked reduction of the enzyme activity; this causes higher homocysteine levels and alterations of folate metabolism. Folate metabolism is essential for DNA synthesis and methylation, crucial steps in carcinogenesis. In this paper, we investigated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18945219
DOI: 10.1111/j.1530-0277.2008.00816.x

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MTHFR C677T polymorphism and risk of HCC in patients with liver cirrhosis: role of male gender and alcohol consumption.PMID 18945219Read ↗

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