Article
Identification of the functional PD-L1 interface region responsible for PD-1 binding and initiation of PD-1 signaling.
The Journal of biological chemistry - 1 Dec 2023
Carter Rachel, Alanazi Fatimah, Sharp Amanda, Roman Jessica, Luchini Alessandra, Liotta Lance, Paige Mikell, Brown Anne M, Haymond Amanda
Abstract excerpt
The PD-1/PD-L1 checkpoint pathway is important for regulating immune responses and can be targeted by immunomodulatory drugs to treat a variety of immune disorders. However, the precise protein-protein interactions required for the initiation of PD-1/PD-L1 signaling are currently unknown. Previously, we designed a series of first-generation PD-1 targeting peptides based on the native interface region of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.