Article
The PS2 integrin ligand tiggrin is required for proper muscle function in Drosophila.
Development (Cambridge, England) - 1 May 1998
Bunch T A, Graner M W, Fessler L I, Fessler J H, Schneider K D, Kerschen A, Choy L P, Burgess B W, Brower D L
Abstract excerpt
Tiggrin is a novel extracellular matrix ligand for the Drosophila PS2 integrins. We have used flanking P elements to generate a precise deletion of tiggrin. Most flies lacking tiggrin die as larvae or pupae. A few adults do emerge and these appear to be relatively normal, displaying only misshape...
Topics
- Abdomen
- Animals
- Animals, Genetically Modified
- Drosophila
- Drosophila Proteins
- Extracellular Matrix Proteins
- Genes, Insect
- Genes, Lethal
- Integrin alpha Chains
- Integrins
- Larva
- Ligands
- Muscle Contraction
- Muscles
- Mutation
- Oligopeptides
- Phenotype
- Pupa