Novel mutations in the BRCA1 and BRCA2 genes in Iranian women with early-onset breast cancer.

doi:10.1186/bcr443

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Novel mutations in the BRCA1 and BRCA2 genes in Iranian women with early-onset breast cancer.

Breast cancer research : BCR - 1 Jan 2002

Yassaee Vahid R, Zeinali Sirous, Harirchi Iraj, Jarvandi Soghra, Mohagheghi Mohammad A, Hornby David P, Dalton Ann

Abstract excerpt

BACKGROUND: Breast cancer is the most common female malignancy and a major cause of death in middle-aged women. So far, germline mutations in the BRCA1 and BRCA2 genes in patients with early-onset breast and/or ovarian cancer have not been identified within the Iranian population. METHODS: With the collaboration of two main centres for cancer in Iran, we obtained clinical information, family history and...

Topics

Adult
Age of Onset
Breast Neoplasms
Codon, Nonsense
DNA Mutational Analysis
DNA, Neoplasm
Exons
Female
Frameshift Mutation
Genes, BRCA1
Genes, BRCA2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Germ-Line Mutation

Humans

Iran

Molecular Sequence Data

Mutation, Missense

Neoplastic Syndromes, Hereditary

Source

Open in PubMed Open full text

Identifiers

PMID: 12100744
DOI: 10.1186/bcr443
PMCID: PMC116720

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel mutations in the BRCA1 and BRCA2 genes in Iranian women with early-onset breast cancer.PMID 12100744Read ↗

Mutation Spectra of BRCA Genes in Iranian Women with Early Onset Breast Cancer - 15 Years Experience.Semantic proximity Read ↗

Mutations and polymorphisms in the familial early-onset breast cancer (BRCA1) gene. Breast Cancer Information Core.Semantic proximity Read ↗

BRCA1 and BRCA2 mutations in women with familial or early-onset breast/ovarian cancer in the Czech Republic.Semantic proximity Read ↗

A comprehensive reference for BRCA1/2 genes pathogenic variants in Iran: published, unpublished and novel.Semantic proximity Read ↗

Mutational analysis of BRCA1 and BRCA2 in Mediterranean Spanish women with early-onset breast cancer: identification of three novel pathogenic mutations.Semantic proximity Read ↗

BRCA1/2 mutations in Swiss patients with familial or early-onset breast and ovarian cancer.Semantic proximity Read ↗

Novel BRCA1 and BRCA2 pathogenic mutations in Slovene hereditary breast and ovarian cancer families.Semantic proximity Read ↗

Mutation spectrum and prevalence of BRCA1 and BRCA2 genes in patients with familial and early-onset breast/ovarian cancer from Tunisia.Semantic proximity Read ↗

Prevalence of germline TP53 variants among early-onset breast cancer patients from Polish population.Semantic proximity Read ↗

BRCA1 and BRCA2 germline mutations in 85 Iranian breast cancer patients.Semantic proximity Read ↗

[Mutational analysis of BRCA1 and BRCA2 genes in early-onset breast cancer patients in Shanghai].Semantic proximity Read ↗

Three novel BRCA1/BRCA2 mutations in breast/ovarian cancer families in Croatia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.