Complete BRCA mutation screening in breast and ovarian cancer predisposition families from a North-Eastern Romanian population.

doi:10.1007/s10689-010-9361-6

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Article

Complete BRCA mutation screening in breast and ovarian cancer predisposition families from a North-Eastern Romanian population.

Familial cancer - 1 Dec 2010

Negura Lucian, Uhrhammer Nancy, Negura Anca, Artenie Vlad, Carasevici Eugen, Bignon Yves-Jean

Abstract excerpt

Breast cancer is the most common cancer in women worldwide, including Romania, where its incidence has increased significantly during the last decade. Ovarian cancer is the fourth leading cause of mortality by cancer in women. BRCA1 and BRCA2 are major cancer predisposition genes, responsible for a large percentage of hereditary breast and ovarian cancer (HBOC) families. We investigated 17 patients from unrelated...

Topics

Adult
BRCA1 Protein
BRCA2 Protein
Breast Neoplasms
DNA Mutational Analysis
DNA, Neoplasm
Family
Female
Genetic Predisposition to Disease
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mass Screening

Mutation

Ovarian Neoplasms

Polymerase Chain Reaction

Polymorphism, Genetic

Risk Factors

Source

Open in PubMed

Identifiers

PMID: 20567915
DOI: 10.1007/s10689-010-9361-6

Genes

BRCA1
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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