Article
Insulin-like growth factor promotes engraftment, differentiation, and functional improvement after transfer of embryonic stem cells for myocardial restoration.
Stem cells (Dayton, Ohio) - 1 Jan 2004
Kofidis Theo, de Bruin Jorg L, Yamane Toshiyuki, Balsam Leora B, Lebl Darren R, Swijnenburg Rutger-Jan, Tanaka Masashi, Weissman Irving L, Robbins Robert C
Abstract excerpt
Insulin-like growth factor-1 (IGF-1) promotes myocyte proliferation and can reverse cardiac abnormalities when it is administered in the early fetal stage. Supplementation of a mouse embryonic stem cell (ESC) suspension with IGF-1 might enhance cellular engraftment and host organ-specific differentiation after injection in the area of acute myocardial injury. In the study reported here, we sought to enhance the...
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