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Article

A synthetic lethal screen identifies a role for the cortical actin patch/endocytosis complex in the response to nutrient deprivation in Saccharomyces cerevisiae.

Genetics - 1 Feb 2004

Care Alison, Vousden Katherine A, Binley Katie M, Radcliffe Pippa, Trevethick Janet, Mannazzu Ilaria, Sudbery Peter E

Abstract excerpt

Saccharomyces cerevisiae whi2Delta cells are unable to halt cell division in response to nutrient limitation and are sensitive to a wide variety of stresses. A synthetic lethal screen resulted in the isolation of siw mutants that had a phenotype similar to that of whi2Delta. Among these were mutations affecting SIW14, FEN2, SLT2, and THR4. Fluid-phase endocytosis is severely reduced or abolished in whi2Delta,...

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Identifiers

PMID: 15020461
DOI: 10.1534/genetics.166.2.707
PMCID: PMC1470737

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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