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Article

The sys-1 and sys-3 genes cooperate with Wnt signaling to establish the proximal-distal axis of the Caenorhabditis elegans gonad.

Genetics - 1 Jan 2004

Siegfried Kellee R, Kidd Ambrose R, Chesney Michael A, Kimble Judith

Abstract excerpt

To form the proximal-distal axis of the C. elegans gonad, two somatic gonadal precursor cells, Z1 and Z4, divide asymmetrically to generate one daughter with a proximal fate and one with a distal fate. Genes governing this process include the lin-17 frizzled receptor, wrm-1/beta-catenin, the pop-1/TCF transcription factor, lit-1/nemo-like kinase, and the sys-1 gene. Normally, all of these regulators promote the...

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Identifiers

PMID: 15020416
DOI: 10.1534/genetics.166.1.171
PMCID: PMC1470708

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