Dexras1 inhibits adenylyl cyclase.

doi:10.1016/j.bbrc.2004.02.049

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Article

Dexras1 inhibits adenylyl cyclase.

Biochemical and biophysical research communications - 2 Apr 2004

Graham T E, Qiao Z, Dorin R I

Abstract excerpt

Dexras1 is a steroid hormone-induced Ras family G protein that acts as a receptor-independent activator of signaling by Gi/o family heterotrimeric G proteins. We examined the effects of Dexras1 on the activity of adenylyl cylase, a target of inhibitory regulation by Gialpha x GTP. Constitutively active Gsalpha (Q227L) increased cAMP levels 43-fold above baseline, and Dexras1 expression inhibited cAMP levels by...

Topics

Adenylyl Cyclase Inhibitors
Adenylyl Cyclases
Cell Line
Cyclic AMP
Cyclic AMP Response Element-Binding Protein
GTP-Binding Protein alpha Subunits, Gi-Go
GTP-Binding Proteins
Humans
Mutation
Pertussis Toxin
Second Messenger Systems
ras Proteins

Source

Open in PubMed

Identifiers

PMID: 15020218
DOI: 10.1016/j.bbrc.2004.02.049

Genes

RGS4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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