Article
Population differences in the frequency of the agouti signaling protein g.8818a>G polymorphism.
Pigment cell research - 1 Apr 2004
Zeigler-Johnson Charnita, Panossian Saarene, Gueye Serigne M, Jalloh Mohamed, Ofori-Adjei David, Kanetsky Peter A
Abstract excerpt
The role of agouti signaling protein (ASIP) in human pigmentation pathways is not definitively understood although its murine homologue regulates, in part, pheomelanogenesis. We have reported an association of a polymorphism in the 3'-untranslated region of ASIP (g.8818A>G) with dark hair and eye color among a group of European-Americans (Am J Hum Genet 2002 March;70:770). Among 147 healthy control subjects, the...
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