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Article

A gene duplication affecting expression of the ovine ASIP gene is responsible for white and black sheep.

Genome research - 1 Aug 2008

Norris Belinda J, Whan Vicki A

Abstract excerpt

Agouti signaling protein (ASIP) functions to regulate pigmentation in mice, while its role in many other animals and in humans has not been fully determined. In this study, we identify a 190-kb tandem duplication encompassing the ovine ASIP and AHCY coding regions and the ITCH promoter region as the genetic cause of white coat color of dominant white/tan (A(Wt)) agouti sheep. The duplication 5' breakpoint is...

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Source

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Identifiers

PMID: 18493018
DOI: 10.1101/gr.072090.107
PMCID: PMC2493430

Genes

ASIP
ITCH
AHCY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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