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Article

The 8818G allele of the agouti signaling protein (ASIP) gene is ancestral and is associated with darker skin color in African Americans.

Human genetics - 1 Apr 2005

Bonilla Carolina, Boxill Lesley-Anne, Donald Stacey Ann Mc, Williams Tyisha, Sylvester Nadeje, Parra Esteban J, Dios Sonia, Norton Heather L, Shriver Mark D, Kittles Rick A

Abstract excerpt

Skin color, a predictor of social interactions and risk factor for several types of cancer, is due to two contrasting forms of melanin, the darker eumelanin and lighter phaeomelanin. The lighter pigment phaeomelanin is the product of the antagonistic function of the agouti signaling protein (ASIP...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15726415
DOI: 10.1007/s00439-004-1251-2

Genes

ASIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15726415-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The 8818G allele of the agouti signaling protein (ASIP) gene is ancestral and is associated with darker skin color in African Americans.PMID 15726415Read ↗

Population differences in the frequency of the agouti signaling protein g.8818a>G polymorphism.Semantic proximity Read ↗

A polymorphism in the agouti signaling protein gene is associated with human pigmentation.Semantic proximity Read ↗

A polymorphism in the agouti signalling protein (ASIP) is associated with decreased levels of mRNA.Semantic proximity Read ↗

Quantitative assessment of skin, hair, and iris variation in a diverse sample of individuals and associated genetic variation.Semantic proximity Read ↗

The contribution of melanocortin 1 receptor gene polymorphisms and the agouti signalling protein gene 8818A>G polymorphism to cutaneous melanoma and basal cell carcinoma in a Polish population.Semantic proximity Read ↗

Identification of a novel locus associated with skin colour in African-admixed populations.Semantic proximity Read ↗

Genetic loci associated with skin pigmentation in African Americans and their effects on vitamin D deficiency.Semantic proximity Read ↗

SLC24A5 and ASIP as phenotypic predictors in Brazilian population for forensic purposes.Semantic proximity Read ↗

A sequence of SVA retrotransposon insertions in ASIP shaped human pigmentation.Semantic proximity Read ↗

Identification of single nucleotide polymorphisms in the agouti signaling protein (ASIP) gene in some goat breeds in tropical and temperate climates.Semantic proximity Read ↗

Skin Color Variation in Orang Asli Tribes of Peninsular MalaysiaSemantic proximity Read ↗

The Arg160Trp allele of melanocortin-1 receptor gene might protect against vitiligo.Semantic proximity Read ↗

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