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Article

A polymorphism in the agouti signaling protein gene is associated with human pigmentation.

American journal of human genetics - 1 Mar 2002

Kanetsky Peter A, Swoyer Jennifer, Panossian Saarene, Holmes Robin, Guerry DuPont, Rebbeck Timothy R

Abstract excerpt

In mice and humans, binding of alpha-melanocyte--stimulating hormone to the melanocyte-stimulating--hormone receptor (MSHR), the protein product of melanocortin-1 receptor (MC1R) gene, leads to the synthesis of eumelanin. In the mouse, ligation of MSHR by agouti signaling protein (ASP) results in the production of pheomelanin. The role of ASP in humans is unclear. We sought to characterize the agouti signaling...

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Source

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Identifiers

PMID: 11833005
DOI: 10.1086/339076
PMCID: PMC384954

Genes

ASIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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