Article
Rho guanine nucleotide exchange factor xNET1 implicated in gastrulation movements during Xenopus development.
Differentiation; research in biological diversity - 1 Feb 2004
Miyakoshi Akira, Ueno Naoto, Kinoshita Noriyuki
Abstract excerpt
During Xenopus development, embryonic cells dramatically change their shape and position. Rho family small GTPases, such as RhoA, Rac, and Cdc42, play important roles in this process. These GTPases are generally activated by guanine nucleotide exchange factors (GEFs); however, the roles of RhoGEFs in Xenopus development have not yet been elucidated. We therefore searched for RhoGEF genes in our Xenopus EST...
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