Article
FcgammaRIIa polymorphism in Japanese patients with systemic lupus erythematosus.
Lupus - 1 Jan 2001
Sato H, Iwano M, Akai Y, Nishino T, Fujimoto T, Shiiki H, Dohi K
Abstract excerpt
Systemic lupus erythematosus (SLE) is an immune complex-mediated disease and organ damage is caused by the deposition of immune complex. Receptors which recognize the Fc portion of immunoglobulin G (FcgammaR) play a key role in the phagocytosis of immune complexes. As the gene encoding for FcgammaR of class IIa (FcgammaRIIa) has two allelic forms, H131 and R131, which differ in their affinity to IgG2, this...
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