Article
Isoproterenol exacerbates a long QT phenotype in Kcnq1-deficient neonatal mice: possible roles for human-like Kcnq1 isoform 1 and slow delayed rectifier K+ current.
The Journal of pharmacology and experimental therapeutics - 1 Jul 2004
Knollmann Bjorn C, Casimiro Mathew C, Katchman Alexander N, Sirenko Syevda G, Schober Tilmann, Rong Qi, Pfeifer Karl, Ebert Steven N
Abstract excerpt
To determine whether the neonatal mouse can serve as a useful model for studying the molecular pharmacological basis of Long QT Syndrome Type 1 (LQT1), which has been linked to mutations in the human KCNQ1 gene, we measured QT intervals from electrocardiogram (ECG) recordings of wild-type (WT) and Kcnq1 knockout (KO) neonates before and after injection with the beta-adrenergic receptor agonist, isoproterenol...
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