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Article

Nicotine induces a long QT phenotype in Kcnq1-deficient mouse hearts.

The Journal of pharmacology and experimental therapeutics - 1 Sept 2003

Tosaka Toshimasa, Casimiro Mathew C, Rong Qi, Tella Srihari, Oh Michelle, Katchman Alexander N, Pezzullo John C, Pfeifer Karl, Ebert Steven N

Abstract excerpt

We have previously shown that targeted disruption of the mouse Kcnq1 gene produces a long QT phenotype in vivo that requires extracardiac factors for manifestation (Casimiro et al., 2001). In the present study, we explore the hypothesis that autonomic neuroeffector transmission represents the "extra cardiac" stimulus that induces a long QT phenotype in mouse hearts lacking Kcnq1. Using the isolated perfused...

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Source

Identifiers

PMID: 12766260
DOI: 10.1124/jpet.103.053017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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