Article
Discrimination between scrapie and bovine spongiform encephalopathy in sheep by molecular size, immunoreactivity, and glycoprofile of prion protein.
Journal of clinical microbiology - 1 Mar 2004
Thuring C M A, Erkens J H F, Jacobs J G, Bossers A, Van Keulen L J M, Garssen G J, Van Zijderveld F G, Ryder S J, Groschup M H, Sweeney T, Langeveld J P M
Abstract excerpt
A procedure for discrimination between scrapie and bovine spongiform encephalopathy (BSE) in sheep is of importance for establishing whether BSE has entered the sheep population. Since BSE has not yet been found in sheep at the farm level, such discrimination procedures can be developed only with experimental sheep BSE. Two distinctive molecular features of the prion protein (PrP)-molecular size and glycosylation...
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