Article
Molecular discrimination of atypical bovine spongiform encephalopathy strains from a geographical region spanning a wide area in Europe.
Journal of clinical microbiology - 1 Jun 2007
Jacobs Jorg G, Langeveld Jan P M, Biacabe Anne-Gaëlle, Acutis Pier-Luigi, Polak Miroslaw P, Gavier-Widen Dolores, Buschmann Anne, Caramelli Maria, Casalone Cristina, Mazza Maria, Groschup Martin, Erkens Jo H F, Davidse Aart, van Zijderveld Fred G, Baron Thierry
Abstract excerpt
Transmissible spongiform encephalopathy strains can be differentiated by their behavior in bioassays and by molecular analyses of the disease-associated prion protein (PrP) in a posttranslationally transformed conformation (PrPSc). Until recently, isolates from cases of bovine spongiform encephalopathy (BSE) appeared to be very homogeneous. However, a limited number of atypical BSE isolates have recently been...
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