Article
Sarcoplasmic reticulum Ca2+ pump mRNA stability in cardiac and smooth muscle: role of poly A+ tail length.
Cell calcium - 1 May 2004
Nie Lin, Khan Islam, Misquitta Christine M, Grover Ashok K
Abstract excerpt
Transcripts of the sarco/endoplasmic reticulum Ca2+ pump SERCA2 are alternatively spliced to produce SERCA2a (expressed in left ventricular muscle (LVM)) and SERCA2b (in stomach smooth muscle (SSM)) mRNA that use different polyadenylation sequences. SERCA2 mRNA in LVM is more stable than in SSM. Here, we report that the SERCA2 poly A+ tail length in LVM (32 +/- 2 bases) is longer than in SSM (20 +/- 1). In the in...
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