Article
Metformin Affects Cortical Bone Mass and Marrow Adiposity in Diet-Induced Obesity in Male Mice.
Endocrinology - 1 Oct 2017
Bornstein Sheila, Moschetta Michele, Kawano Yawara, Sacco Antonio, Huynh Daisy, Brooks Daniel, Manier Salomon, Fairfield Heather, Falank Carolyne, Roccaro Aldo M, Nagano Kenichi, Baron Roland, Bouxein Mary, Vary Calvin, Ghobrial Irene M, Rosen Clifford J, Reagan Michaela R
Abstract excerpt
Obesity during maturation can affect the growing skeleton directly and indirectly, although these effects and the mechanisms behind them are not fully understood. Our objective was to determine how a high-fat diet with or without metformin treatment affects skeletal development. We also sought to characterize changes that occur in white adipose tissue, circulating metabolites, lipids, and gut microbiota. A...
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