Article
Effect of Leptin Deficiency on the Skeletal Response to Hindlimb Unloading in Adult Male Mice.
Scientific reports - 27 Jun 2019
Keune Jessica A, Branscum Adam J, Wong Carmen P, Iwaniec Urszula T, Turner Russell T
Abstract excerpt
Based on body weight, morbidly obese leptin-deficient ob/ob mice have less bone than expected, suggesting that leptin plays a role in the skeletal response to weight bearing. To evaluate this possibility, we compared the skeletal response of wild type (WT) and ob/ob mice to hindlimb unloading (HU). Mice were individually housed at 32 °C (thermoneutral) from 4 weeks of age (rapidly growing) to 16 weeks of age...
Topics
- Age Factors
- Animals
- Biomarkers
- Bone Density
- Bone Development
- Bone and Bones
- Genetic Association Studies
- Genotype
- Hindlimb Suspension
- Imaging, Three-Dimensional
- Immunohistochemistry