Article
Flt3 mutation activates p21WAF1/CIP1 gene expression through the action of STAT5.
Biochemical and biophysical research communications - 26 Mar 2004
Takahashi Shinichiro, Harigae Hideo, Kaku Mitsuo, Sasaki Takeshi, Licht Jonathan D
Abstract excerpt
Flt3 is a type III RTK and approximately 30% of AML patients harbor an internal tandem duplication (ITD) of the juxtamembrane region or a point mutation of the Flt3 protein leading to the constitutive activation of downstream signaling pathways and aberrant cell growth. The cyclin-dependent kinase inhibitor p21 inhibits cell growth when expressed at high levels and induces cell growth when expressed at lower...
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