Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thrombopoietin-Induced Differentiation of a Human Megakaryoblastic Leukemia Cell Line, CMK, Involves Transcriptional Activation of p21 WAF1/Cip1 by STAT5

1 May 1997

Abstract excerpt

Although thrombopoietin (TPO) is known to play a fundamental role in both megakaryopoiesis and thrombopoiesis, the molecular mechanism of TPO-induced megakaryocytic differentiation is not known. In a human megakaryoblastic leukemia cell line, CMK, that showed some degree of megakaryocytic differentiation after culture with TPO, the cyclin-dependent kinase (Cdk) inhibitor p21(WAF1/Cip1), but not p27(Kip1),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Lymphocytic Leukemia Research
Share to Lipid metabolism and disorders
Share to Platelet Disorders and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9111365
DOI: 10.1128/mcb.17.5.2933

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thrombopoietin-Induced Differentiation of a Human Megakaryoblastic Leukemia Cell Line, CMK, Involves Transcriptional Activation of p21 WAF1/Cip1 by STAT5PMID 9111365Read ↗

p21Cip1 and p27Kip1 Induce Distinct Cell Cycle Effects and Differentiation Programs in Myeloid Leukemia CellsSemantic proximity Read ↗

Role of p21Cip1/Waf1 in cell-cycle exit of endomitotic megakaryocytesSemantic proximity Read ↗

A Senescence-Like Cell-Cycle Arrest Occurs During Megakaryocytic Maturation: Implications for Physiological and Pathological Megakaryocytic ProliferationSemantic proximity Read ↗

Thrombopoietin-mediated sustained activation of extracellular signal-regulated kinase in UT7-Mpl cells requires both Ras-Raf-1- and Rap1-B-Raf-dependent pathways.Semantic proximity Read ↗

Flt3 mutation activates p21WAF1/CIP1 gene expression through the action of STAT5.Semantic proximity Read ↗

P19INK4D links endomitotic arrest and megakaryocyte maturation and is regulated by AML-1Semantic proximity Read ↗

Induction of polyploidization in leukemic cell lines and primary bone marrow by Src kinase inhibitor SU6656Semantic proximity Read ↗

The microRNA-26a target E2F7 sustains cell proliferation and inhibits monocytic differentiation of acute myeloid leukemia cellsSemantic proximity Read ↗

Transforming growth factor β-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulationSemantic proximity Read ↗

Cell cycle–dependent centrosome clustering precedes proplatelet formationSemantic proximity Read ↗

Downregulation of an Aim-1 Kinase Couples with Megakaryocytic Polyploidization of Human Hematopoietic CellsSemantic proximity Read ↗

Cyclin D3 and megakaryocyte development: exploration of a transgenic phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.