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Article

Sensitivity to CPT-11 of xenografted human colorectal cancers as a function of microsatellite instability and p53 status.

British journal of cancer - 1 Feb 2000

Bras-Gonçalves R A, Rosty C, Laurent-Puig P, Soulié P, Dutrillaux B, Poupon M F

Abstract excerpt

Biological parameters influencing the response of human colorectal cancers (CRCs) to CPT-11, a topoisomerase 1 (top1) inhibitor, were investigated using a panel of nine CRCs xenografted into nude mice. CRC xenografts differed in their p53 status (wt or muf) and in their microsatellite instability phenotype (MSI+ when altered). Five CRC xenografts were established from clinical samples. All five had a functional...

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Source

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Identifiers

PMID: 10732766
DOI: 10.1054/bjoc.1999.1019
PMCID: PMC2374412

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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