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Article

Structural basis for the RING-catalyzed synthesis of K63-linked ubiquitin chains.

Nature structural & molecular biology - 1 Aug 2015

Branigan Emma, Plechanovová Anna, Jaffray Ellis G, Naismith James H, Hay Ronald T

Abstract excerpt

RING E3 ligase-catalyzed formation of K63-linked ubiquitin chains by the Ube2V2-Ubc13 E2 complex is required in many important biological processes. Here we report the structure of the RING-domain dimer of rat RNF4 in complex with a human Ubc13∼Ub conjugate and Ube2V2. The structure has captured Ube2V2 bound to the acceptor (priming) ubiquitin with K63 in a position favorable for attack on the linkage between...

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Source

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Identifiers

PMID: 26148049
DOI: 10.1038/nsmb.3052
PMCID: PMC4529489

Genes

RNF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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