Article
HIV type 1 genotypic resistance in a clinical database correlates with antiretroviral utilization.
AIDS research and human retroviruses - 1 Jan 2004
Kagan Ron, Winters Mark, Merigan Thomas, Heseltine Peter
Abstract excerpt
We established a database of HIV-1 reverse transcriptase (RT) and protease (PR) sequences and mutations to monitor the prevalence of antiretroviral drug resistance and mutational patterns in clinical samples submitted for testing to a major U.S. reference laboratory. At the end of 1998, 80% of the clinical samples tested harbored HIV strains with genotypically predicted resistance to at least one antiretroviral...
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