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Inactivation of the <i>Mgat1</i> Gene in Oocytes Impairs Oogenesis, but Embryos Lacking Complex and Hybrid N<i>-</i>Glycans Develop and Implant

28 Oct 2004

Abstract excerpt

Complex and hybrid N-glycans contain sugar residues that have been implicated in fertilization, compaction of the embryo, and implantation. Inactivation of the Mgat1 gene responsible for their synthesis is embryonic lethal, but homozygous mutant blastocysts are phenotypically normal due to the presence of maternal Mgat1 gene transcripts. To identify roles for complex and hybrid N-glycans in oogenesis and...

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PMID: 15509794
DOI: 10.1128/mcb.24.22.9920-9929.2004

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