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A naturally occurring NAR variable domain binds the Kgp protease from <i>Porphyromonas gingivalis</i>

12 Mar 2002

Abstract excerpt

The new antigen receptor (NAR) from sharks consists of a single immunoglobulin variable domain attached to five constant domains, and is hypothesised to function as an antibody. Two closely related NARs with affinity for the Kgp (lysine-specific) gingipain protease from Porphyromonas gingivalis were selected by panning an NAR variable domain library. When produced in Escherichia coli, these recombinant NARs were...

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PMID: 11959108
DOI: 10.1016/s0014-5793(02)02506-1

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