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Article

Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs.

Nature communications - 9 Jul 2021

Xu Kai, Wang Yiran, Shen Chen-Hsiang, Chen Yiwei, Zhang Baoshan, Liu Kevin, Tsybovsky Yaroslav, Wang Shuishu, Farney S Katie, Gorman Jason, Stephens Tyler, Verardi Raffaello, Yang Yongping, Zhou Tongqing, Chuang Gwo-Yu, Lanzavecchia Antonio, Piccoli Luca, Kwong Peter D

Abstract excerpt

RIFIN, a large family of Plasmodium variant surface antigens, plays a crucial role in malaria pathogenesis by mediating immune suppression through activation of inhibitory receptors such as LAIR1, and antibodies with LAIR1 inserts have been identified that bind infected erythrocytes through RIFIN. However, details of RIFIN-mediated LAIR1 recognition and receptor activation have been unclear. Here, we use...

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Identifiers

PMID: 34244481
DOI: 10.1038/s41467-021-24291-6
PMCID: PMC8270905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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