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Isolation and characterization of malaria PfHRP2 specific VNAR antibody fragments from immunized shark phage display library

24 Oct 2018

Abstract excerpt

Malaria rapid diagnostic tests (RDTs) represent an important antibody based immunoassay platform. Unfortunately, conventional monoclonal antibodies are subject to degradation shortening shelf lives of RDTs. The variable region of the receptor (V NAR ) from shark has a potential as alternative to monoclonal antibodies in RDTs due to high thermal stability. In this study, new binders derived from shark V NAR...

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PMID: 30355309
DOI: 10.1186/s12936-018-2531-y

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