Article
Convergent signaling in the regulation of connective tissue growth factor in malignant mesothelioma: TGFβ signaling and defects in the Hippo signaling cascade.
Cell cycle (Georgetown, Tex.) - 15 Sept 2012
Fujii Makiko, Nakanishi Hayao, Toyoda Takeshi, Tanaka Ichidai, Kondo Yutaka, Osada Hirotaka, Sekido Yoshitaka
Abstract excerpt
Malignant mesothelioma (MM) is a neoplasm that arises from serosal surfaces of the pleural, peritoneal and pericardial cavities with worldwide incidence, much of which is caused by asbestos exposure. Patients suffer from pain and dyspnea due to direct invasion of the chest wall, lungs and vertebral or intercostal nerves by masses of thick fibrotic tumors. Although there has been recent progress in the clinical...
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