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Article

CD4(+) T-cell recognition of mutated B-RAF in melanoma patients harboring the V599E mutation.

Cancer research - 1 Mar 2004

Sharkey Melinda S, Lizée Gregory, Gonzales Monica I, Patel Sima, Topalian Suzanne L

Abstract excerpt

The potential of antigen-directed cancer immunotherapy has not been fully realized, perhaps because many commonly targeted tumor associated proteins are not essential to maintaining the malignant cell phenotype. A constitutively activating mutation in the signaling molecule BRAF is expressed frequently in melanomas and may play an important role in the biology of this disease. A 29-mer B-Raf peptide incorporating...

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Source

Identifiers

PMID: 14996715
DOI: 10.1158/0008-5472.can-03-3231

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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CD4(+) T-cell recognition of mutated B-RAF in melanoma patients harboring the V599E mutation.PMID 14996715Read ↗

Human leukocyte antigen-A2-restricted CTL responses to mutated BRAF peptides in melanoma patients.Semantic proximity Read ↗

Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors.Semantic proximity Read ↗

Immunogenicity of constitutively active V599EBRaf.Semantic proximity Read ↗

V599EB-RAF is an Oncogene in MelanocytesSemantic proximity Read ↗

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Effects of BRAF mutations and BRAF inhibition on immune responses to melanoma.Semantic proximity Read ↗

BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma.Semantic proximity Read ↗

Identification of tumor-associated, MHC class II-restricted phosphopeptides as targets for immunotherapy.Semantic proximity Read ↗

Shifting the Balance of Activating and Inhibitory Natural Killer Receptor Ligands on BRAFV600E Melanoma Lines with Vemurafenib.Semantic proximity Read ↗

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A ras- Mutated Peptide Targeted by CTL Infiltrating a Human Melanoma LesionSemantic proximity Read ↗

Multiple HLA-A alleles can present an immunodominant peptide of the human melanoma antigen Melan-A/MART-1 to a peptide-specific HLA-A*0201+ cytotoxic T cell line.Semantic proximity Read ↗

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